[10] Leyton Orient 3-0 Exeter [15] 2021-07-25 14:00
Stadium: Matchroom Stadium Round: 2
Referee: Tom Reeves Home Manager: Kenneth Francis Jackett Away Manager: Matthew Taylor
Head to Head
| England League 2 | 2021/03/06 13:00 | Exeter v Leyton Orient | L | 4-0 |
| England League 2 | 2020/10/27 19:00 | Leyton Orient v Exeter | D | 1-1 |
| England League 2 | 2019/09/14 14:00 | Exeter v Leyton Orient | D | 2-2 |
| England League 2 | 2017/01/02 15:00 | Exeter v Leyton Orient | L | 4-0 |
| England League 2 | 2016/11/22 19:45 | Leyton Orient v Exeter | L | 0-1 |
| England League 2 | 2016/01/16 15:00 | Leyton Orient v Exeter | L | 1-3 |
| England League 2 | 2015/09/05 14:00 | Exeter v Leyton Orient | L | 4-0 |
Home History
| Club Friendly List | 2021/07/24 14:00 | Maidenhead Utd v Leyton Orient | W | 1-2 |
| Elite Club Friendlies | 2021/07/17 14:00 | Leyton Orient v Tottenham | D | 1-1 |
| Elite Club Friendlies | 2021/07/13 18:00 | Leyton Orient v West Ham | D | 0-0 |
| UK Friendlies | 2021/07/13 18:00 | Leyton Orient v West Ham XI | D | 0-0 |
| Club Friendly List | 2021/07/06 16:00 | Dundee v Leyton Orient | L | 3-0 |
| England League 2 | 2021/05/08 15:00 | Salford City v Leyton Orient | L | 3-0 |
| England League 2 | 2021/05/01 14:00 | Leyton Orient v Carlisle | L | 2-3 |
| England League 2 | 2021/04/24 14:00 | Southend v Leyton Orient | L | 2-1 |
Away History
| Club Friendly List | 2021/07/24 12:00 | Cardiff v Exeter | D | 2-2 |
| Club Friendly List | 2021/07/20 18:30 | Weymouth v Exeter | W | 2-3 |
| Club Friendly List | 2021/07/16 18:00 | Bath City v Exeter | W | 3-4 |
| Club Friendly List | 2021/07/13 18:30 | Taunton Town v Exeter | W | 0-5 |
| Club Friendly List | 2021/07/09 18:30 | Tiverton Town v Exeter | W | 0-1 |
| Club Friendly List | 2021/07/06 18:45 | Weston Super Mare v Exeter | L | 2-1 |
| England League 2 | 2021/05/08 14:00 | Exeter v Barrow | D | 1-1 |
| England League 2 | 2021/05/01 14:00 | Bolton v Exeter | W | 1-2 |