[4] Northampton 32-31 Harlequins [3] 2022-03-20 18:45
Stadium: Franklin's Gardens Round: 24
Referee: Matthew Carley
Head to Head
| Premiership Rugby | 2021/12/27 17:00 | Harlequins v Northampton | L | 41-27 |
| Prem Rugby Cup | 2021/11/19 19:45 | Harlequins v Northampton | L | 26-25 |
| Premiership Rugby | 2021/03/07 15:00 | Harlequins v Northampton | L | 37-19 |
| Premiership Rugby | 2020/11/28 14:00 | Northampton v Harlequins | L | 29-49 |
| Premiership Rugby | 2020/08/30 13:00 | Harlequins v Northampton | L | 30-17 |
| Premiership Rugby | 2019/11/01 19:45 | Northampton v Harlequins | W | 40-22 |
| Premiership Rugby | 2019/04/13 14:00 | Harlequins v Northampton | W | 19-20 |
| Premiership Rugby | 2018/09/07 18:45 | Northampton v Harlequins | W | 25-18 |
Home History
| Prem Rugby Cup | 2022/03/19 15:00 | Saracens v Northampton | W | 35-46 |
| Premiership Rugby | 2022/03/13 15:00 | Northampton v Wasps | W | 27-22 |
| Premiership Rugby | 2022/03/05 15:00 | Gloucester v Northampton | L | 35-30 |
| Premiership Rugby | 2022/02/27 13:00 | Northampton v Exeter Chiefs | L | 31-34 |
| Premiership Rugby | 2022/02/19 15:00 | Northampton v Sale Sharks | L | 21-22 |
| Premiership Rugby | 2022/02/11 19:45 | Leicester v Northampton | L | 35-20 |
| Premiership Rugby | 2022/01/29 15:00 | Worcester Warriors v Northampton | W | 13-29 |
| European Rugby Champions Cup | 2022/01/23 15:15 | Racing 92 v Northampton | L | 28-0 |
Away History
| Prem Rugby Cup | 2022/03/18 19:45 | London Irish v Harlequins | L | 34-19 |
| Premiership Rugby | 2022/03/13 15:00 | Bristol v Harlequins | W | 29-38 |
| Premiership Rugby | 2022/03/04 19:45 | Harlequins v Newcastle Red Bulls | W | 24-10 |
| Premiership Rugby | 2022/02/25 19:45 | Worcester Warriors v Harlequins | W | 21-29 |
| Premiership Rugby | 2022/02/19 15:00 | Harlequins v Wasps | W | 29-24 |
| Premiership Rugby | 2022/02/13 13:00 | Saracens v Harlequins | L | 19-10 |
| Premiership Rugby | 2022/02/06 13:00 | Harlequins v Sale Sharks | L | 14-36 |
| Premiership Rugby | 2022/01/28 19:45 | Bath v Harlequins | L | 21-17 |