[30] HOU Texans 3-31 IND Colts [29] 2021-07-18 21:00
Stadium: Lucas Oil Stadium Round: 1
Home Manager: Frank Reich Away Manager: David Culley
Head to Head
| NFL | 2020/12/20 18:00 | HOU Texans v IND Colts | L | 20-27 |
| NFL | 2020/12/06 18:00 | IND Colts v HOU Texans | L | 26-20 |
| NFL | 2019/11/22 01:20 | IND Colts v HOU Texans | W | 17-20 |
| NFL | 2019/10/20 17:00 | HOU Texans v IND Colts | L | 23-30 |
| NFL | 2019/01/05 21:35 | IND Colts v HOU Texans | L | 21-7 |
| NFL | 2018/12/09 18:00 | IND Colts v HOU Texans | L | 24-21 |
| NFL | 2018/09/30 17:00 | HOU Texans v IND Colts | W | 37-34 |
| NFL | 2017/12/31 18:00 | HOU Texans v IND Colts | L | 13-22 |
Home History
| NFL | 2021/01/03 21:25 | TEN Titans v HOU Texans | L | 41-38 |
| NFL | 2020/12/27 18:00 | CIN Bengals v HOU Texans | L | 37-31 |
| NFL | 2020/12/20 18:00 | HOU Texans v IND Colts | L | 20-27 |
| NFL | 2020/12/13 18:00 | HOU Texans v CHI Bears | L | 7-36 |
| NFL | 2020/12/06 18:00 | IND Colts v HOU Texans | L | 26-20 |
| NFL | 2020/11/26 17:30 | HOU Texans v DET Lions | W | 41-25 |
| NFL | 2020/11/22 18:00 | NE Patriots v HOU Texans | W | 20-27 |
| NFL | 2020/11/15 18:00 | HOU Texans v CLE Browns | L | 7-10 |
Away History
| NFL | 2021/01/09 18:05 | IND Colts v BUF Bills | L | 24-27 |
| NFL | 2021/01/03 21:25 | JAX Jaguars v IND Colts | W | 14-28 |
| NFL | 2020/12/27 18:00 | IND Colts v PIT Steelers | L | 24-28 |
| NFL | 2020/12/20 18:00 | HOU Texans v IND Colts | W | 20-27 |
| NFL | 2020/12/13 21:05 | IND Colts v LV Raiders | W | 44-27 |
| NFL | 2020/12/06 18:00 | IND Colts v HOU Texans | W | 26-20 |
| NFL | 2020/11/29 18:00 | TEN Titans v IND Colts | L | 45-26 |
| NFL | 2020/11/22 21:25 | GB Packers v IND Colts | W | 31-34 |