[11] SJ Sharks 3-2 BUF Sabres [14] 2021-11-23 20:00
Stadium: KeyBank Center
Home Manager: Don Granato Away Manager: Bob Boughner
Head to Head
| NHL | 2021/11/03 02:30 | BUF Sabres v SJ Sharks | W | 3-5 |
| NHL | 2019/10/22 23:00 | SJ Sharks v BUF Sabres | L | 3-4 |
| NHL | 2019/10/20 02:30 | BUF Sabres v SJ Sharks | L | 4-3 |
| NHL | 2018/11/28 00:00 | SJ Sharks v BUF Sabres | L | 2-3 |
| NHL | 2018/10/19 02:30 | BUF Sabres v SJ Sharks | W | 1-5 |
| NHL | 2017/10/28 17:00 | SJ Sharks v BUF Sabres | W | 3-2 |
| NHL | 2017/10/13 02:30 | BUF Sabres v SJ Sharks | W | 2-3 |
| NHL | 2017/03/15 02:30 | BUF Sabres v SJ Sharks | W | 1-4 |
Home History
| NHL | 2021/11/23 03:30 | CAR Hurricanes v SJ Sharks | W | 1-2 |
| NHL | 2021/11/21 03:30 | WAS Capitals v SJ Sharks | L | 4-0 |
| NHL | 2021/11/19 01:00 | SJ Sharks v STL Blues | L | 1-4 |
| NHL | 2021/11/17 01:00 | SJ Sharks v MIN Wild | W | 4-1 |
| NHL | 2021/11/14 02:00 | SJ Sharks v COL Avalanche | L | 2-6 |
| NHL | 2021/11/12 01:00 | SJ Sharks v WIN Jets | L | 1-4 |
| NHL | 2021/11/10 02:00 | SJ Sharks v CAL Flames | W | 4-1 |
| NHL | 2021/11/07 02:30 | NJ Devils v SJ Sharks | L | 3-2 |
Away History
| NHL | 2021/11/23 00:00 | CLB Blue Jackets v BUF Sabres | L | 7-4 |
| NHL | 2021/11/21 23:00 | BUF Sabres v NY Rangers | L | 4-5 |
| NHL | 2021/11/19 00:00 | CAL Flames v BUF Sabres | L | 5-0 |
| NHL | 2021/11/17 00:00 | BUF Sabres v PIT Penguins | W | 2-1 |
| NHL | 2021/11/14 00:00 | TOR Maple Leafs v BUF Sabres | L | 5-4 |
| NHL | 2021/11/13 00:00 | EDM Oilers v BUF Sabres | W | 2-3 |
| NHL | 2021/11/09 00:00 | BUF Sabres v WAS Capitals | L | 3-5 |
| NHL | 2021/11/06 23:00 | DET Red Wings v BUF Sabres | L | 4-3 |