[16] BUF Sabres 1-5 PIT Penguins [6] 2017-10-14 10:00
Stadium: PPG Paints Arena Round: 1
Home Manager: Mike Sullivan Away Manager: Phil Housley
Head to Head
| NHL Pre-Season | 2017/09/27 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2017/09/19 23:00 | PIT Penguins v BUF Sabres | W | 3-4 |
| NHL | 2017/03/21 23:00 | PIT Penguins v BUF Sabres | L | 3-1 |
| NHL | 2017/03/05 22:00 | BUF Sabres v PIT Penguins | L | 3-4 |
| NHL | 2016/11/20 00:00 | PIT Penguins v BUF Sabres | W | 1-2 |
Home History
| NHL | 2017/10/13 02:30 | BUF Sabres v SJ Sharks | L | 2-3 |
| NHL | 2017/10/09 19:00 | NJ Devils v BUF Sabres | L | 6-2 |
| NHL | 2017/10/07 23:00 | NY Islanders v BUF Sabres | L | 6-3 |
| NHL | 2017/10/05 23:00 | MON Canadiens v BUF Sabres | L | 3-2 |
| NHL Pre-Season | 2017/09/29 23:00 | NY Islanders v BUF Sabres | L | 3-1 |
| NHL Pre-Season | 2017/09/27 23:00 | BUF Sabres v PIT Penguins | L | 4-5 |
| NHL Pre-Season | 2017/09/23 23:00 | BUF Sabres v TOR Maple Leafs | L | 1-3 |
| NHL Pre-Season | 2017/09/22 23:30 | BUF Sabres v TOR Maple Leafs | L | 0-3 |
Away History
| NHL | 2017/10/12 23:30 | TB Lightning v PIT Penguins | L | 5-4 |
| NHL | 2017/10/11 23:30 | PIT Penguins v WAS Capitals | W | 3-2 |
| NHL | 2017/10/07 23:00 | PIT Penguins v NAS Predators | W | 4-0 |
| NHL | 2017/10/06 00:30 | PIT Penguins v CHI Blackhawks | L | 1-10 |
| NHL | 2017/10/05 00:00 | STL Blues v PIT Penguins | L | 5-4 |
| NHL Pre-Season | 2017/09/30 20:00 | CLB Blue Jackets v PIT Penguins | L | 3-0 |
| NHL Pre-Season | 2017/09/27 23:00 | BUF Sabres v PIT Penguins | W | 4-5 |
| NHL Pre-Season | 2017/09/25 23:30 | PIT Penguins v DET Red Wings | L | 1-4 |