Stadium: Thompson-Boling Arena
Home Manager: Kenny Brooks Away Manager: Kellie Harper
| WNCAAB | 2022/03/18 18:30 | Florida Gulf Coast (W) v Virginia Tech (W) | L | 84-81 |
| WNCAAB | 2022/03/05 17:00 | NC State (W) v Virginia Tech (W) | L | 70-55 |
| WNCAAB | 2022/03/04 16:00 | North Carolina (W) v Virginia Tech (W) | W | 80-87 |
| WNCAAB | 2022/03/03 16:00 | Clemson (W) v Virginia Tech (W) | W | 60-82 |
| WNCAAB | 2022/02/27 23:00 | NC State (W) v Virginia Tech (W) | L | 68-66 |
| WNCAAB | 2022/02/24 23:00 | Miami Florida (W) v Virginia Tech (W) | W | 63-70 |
| WNCAAB | 2022/02/20 19:00 | Virginia Tech (W) v Louisville (W) | L | 56-70 |
| WNCAAB | 2022/02/18 00:00 | Virginia Tech (W) v Syracuse (W) | W | 102-53 |
| WNCAAB | 2022/03/26 20:00 | Tennessee (W) v Louisville (W) | L | 64-76 |
| WNCAAB | 2022/03/21 23:00 | Belmont (W) v Tennessee (W) | W | 67-70 |
| WNCAAB | 2022/03/19 19:00 | Buffalo Women v Tennessee (W) | W | 67-80 |
| WNCAAB | 2022/03/06 00:30 | Tennessee (W) v Kentucky (W) | L | 74-83 |
| WNCAAB | 2022/03/05 02:30 | Alabama (W) v Tennessee (W) | W | 59-74 |
| WNCAAB | 2022/02/27 19:00 | LSU (W) v Tennessee (W) | L | 57-54 |
| WNCAAB | 2022/02/24 23:30 | Mississippi State (W) v Tennessee (W) | W | 64-86 |
| WNCAAB | 2022/02/20 18:00 | Tennessee (W) v South Carolina (W) | L | 53-67 |