Stadium: Hart Center Arena
Home Manager: Kara Kelly Away Manager: Maureen Magarity
| NIT Women | 2022/03/16 23:00 | Holy Cross (W) v Columbia (W) | L | 69-80 |
| WNCAAB | 2022/03/08 00:00 | Navy (W) v Holy Cross (W) | L | 50-49 |
| WNCAAB | 2022/03/02 23:00 | Boston U (W) v Holy Cross (W) | W | 48-59 |
| WNCAAB | 2022/02/26 18:00 | Holy Cross (W) v Army (W) | W | 73-59 |
| WNCAAB | 2022/02/24 00:00 | Holy Cross (W) v Colgate (W) | W | 62-55 |
| WNCAAB | 2022/02/19 17:00 | Navy (W) v Holy Cross (W) | W | 57-63 |
| WNCAAB | 2022/02/16 23:00 | Holy Cross (W) v Boston U (W) | L | 56-74 |
| WNCAAB | 2022/02/12 17:00 | Bucknell (W) v Holy Cross (W) | L | 66-49 |